New amylase inhibitor (S-AI) from Streptomyces diastaticus var. amylostaticus No. 2476.
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چکیده
منابع مشابه
A tailoring activity is responsible for generating polyene amide derivatives in Streptomyces diastaticus var. 108.
We recently characterized rimocidin B (3b) and CE-108B (4b) as two polyene amides with improved pharmacological properties, produced by genetically modified Streptomyces diastaticus var. 108. In this work, genetic and biochemical analysis of the producer strain show that the two amides are derived from the parental polyenes rimocidin (3a) and CE-108 (4a) by a post-PKS modification of the free s...
متن کاملNoteAn Inhibitor of S - Hemolysin , SHI , Producedby Streptomyces sp . Strain No . 6288
is a unique phospholipase C with a high substrate specificity for sphingemyelin. Moreever, the strain atso produced two kinds of phospholipase inhibitors, designated as SHI and S-PLI, in different phases of cultivation. The purified SHI wss shown to be a basic substance containing an amino group and glycoside moiety, and it was a more effet tive inhibitor of S-Hemoiysin and sphingomyelinase fte...
متن کاملPhevalin, a new calpain inhibitor, from a Streptomyces sp.
Calpain is a Ca2 + -dependent cysteine protease which is found in the microsomal and cytosolic compartments of most mammalianneurons and other cells1}. Calpain hydrolyses peptide bonds of proteins in the cytosol2'3). A large amount of research effort has been focused on this enzyme, since it potentially plays a central role in several physiological events, such as turnover of myofibrillar prote...
متن کاملNew Rimocidin/CE-108 Derivatives Obtained by a Crotonyl-CoA Carboxylase/Reductase Gene Disruption in Streptomyces diastaticus var. 108: Substrates for the Polyene Carboxamide Synthase PcsA
The rimJ gene, which codes for a crotonyl-CoA carboxylase/reductase, lies within the biosynthetic gene cluster for two polyketides belonging to the polyene macrolide group (CE-108 and rimocidin) produced by Streptomyces diastaticus var. 108. Disruption of rimJ by insertional inactivation gave rise to a recombinant strain overproducing new polyene derivatives besides the parental CE-108 (2a) and...
متن کاملBioactivity-Guided Separation of an α-Amylase Inhibitor Flavonoid from Salvia virgata
It is now believed that the inhibition of carbohydrate hydrolyzing enzymes (CHEs) in the digestive tract can significantly prolong the overall carbohydrate digestion time and decrease the postprandial hyperglycemia after a meal. Therefore, inhibitors of CHEs can be useful therapeutic approaches in the management of diabetes mellitus, especially in the type 2, and complications associated with t...
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ژورنال
عنوان ژورنال: Agricultural and Biological Chemistry
سال: 1975
ISSN: 0002-1369,1881-1280
DOI: 10.1271/bbb1961.39.2271